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Here, we show that fmd cycles reduce cognitive decline and ad pathology in e4fad and 3xtg ad mouse models, with effects superior to those caused by protein restriction cycles. Periodic fasting mimicking diet (fmd) cycles are emerging as promising enhancers of a wide range of cancer therapies including immunotherapy. Since most current ad drugs that target aβ seem to have limited efficacy, a diet like fmd appears to have more potential for slowing or even preventing ad progression.

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Recent clinical trials show fmd can lower biological age by 2.5 years, enhance insulin sensitivity and reduce liver fat, making it a promising strategy for improving healthspan. In this study, the authors demonstrated that fmd cycles have a more significant effect on reducing ad pathology and cognitive decline than cycles of protein restriction in mouse models.