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It can occur due to prolonged administration of propofol (an anesthetic) in. Background pris = propofol infusion syndrome refractory bradycardia and cardiovascular collapse poorly understood mechanism risk factors high doses of (> 4mg/kg/hr or 67 mcg/kg/min) long. Aside from propofol dose, other risk factors for pris include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease.

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Mechanism of pris high doses of propofol (greater than 3mg/kg/h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic. Pris was defined as metabolic acidosis plus cardiac dysfunction and at least one other variable including the fact that hypertriglyceridemia, rhabdomyolysis, and acute kidney injury occurred. Propofol infusion syndrome (pris) is a rare and potentially fatal condition that was first reported in children in 1990

It is characterized by profound metabolic acidosis and.

General measures to support cardiac and renal function should be initiated promptly in patients.